[8] Spinosad residues are highly stable on grains stored in bins, with protection ranging from 6 months to 2 years. SPINOSAD (203) IDENTITY ... ISO common name: spinosad. Brand names: Natroba. Spinosoid binding leads to disruption of acetylcholine neurotransmission. This drug has forty-eight patent family members in thirty countries. [2] Spinosad is relatively nonpolar and not easily dissolved in water. Spinosad topical suspension, 0.9%, was approved by the U.S. Food and Drug Administration (FDA) on 2011-01-18 for the topical treatment of head lice infestation in patients four (4) years of age and older. The product's dosage form is suspension and is administered via topical form. Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. Ecotoxicology parameters have been reported for spinosad, and are:[14], Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. Spinosad is a metabolite produced by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa. Spinosad 0.9% topical suspension is used to treat head lice infestations. Natroba; Descriptions. SC […] Abamectin, Avid as it is often referred to in the generic, is an insecticide, acaricide and nematicide most commonly used by gardeners and the agriculture industry to fight off mites. Pyriproxyfen has low acute toxicity. The tri-O-methylrhamnose at the 9-position of the 17-pseudoaglycone of spinosyn A was hydrolyzed under more vigorous acidic conditions to give the aglycone of spinosyn A. Spread the knowledgeHi all, I have collected a list of all the major insecticides available in the market and arranged them in a learn-able organized tabular form. In the US, pyriproxyfen is often marketed under the trade name Nylar. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. Uses. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. spinosad ( spy -no-sad) , Natroba (trade name) Classification Therapeutic: pediculocides Pregnancy Category: B Indications Treatment of head lice in adults and children >4 yr. Action Causes neuronal hyperexcitation in insects, resulting paralysis and death of lice. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. Known as a developmental or reproductive toxin in humans, this chemical is highly toxic to aquatic life. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. Spinosad is also commonly used to kill thrips. Spinosad has a unique mode of action that is different from all other known insect control products.It represents a new class of highly effective and safest insect control agent with superior and consistent control. However, these conditions led to decomposition of the 17-pseudoaglycone of … It is used to control a wide variety of pests. 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